Yasunori Saheki, M.D., Ph.D. Nanyang Assistant Professor Principle Investigator Cell Biology and Molecular Neuroscience Laboratory, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
Yasunoriattended Okayama University Medical School in Okayama, Japan, obtaining his MD in 2005. He then pursued his graduate studies at the Rockefeller University in New York, USA. Working in the laboratory of Dr. Cori Bargmann, he investigated the mechanisms of ion channel localization at the nerve terminals using C. elegans. After receiving his PhD in Neurobiology in 2010, Yasunori moved to the Yale University School of Medicine in New Haven, where he worked as a postdoctoral fellow in the laboratory of Dr. Pietro De Camilli, supported by fellowships from the Uehara memorial foundation and the Japan Society for the Promotion of Science. Using a combination of genome editing, biochemistry, quantitative cellular imaging, and optogenetics, he studied the regulatory mechanisms that govern cellular lipid homeostasis. Yasunori joined the faculty at Lee Kong Chian School of Medicine as a Nanyang Assistant Professor in March, 2016. His laboratory employs the combination of C. elegans genetics and mammalian cell biology to tackle fundamental questions in cellular lipid regulation as well as the mechanisms that underlie neurological disorders.
Darshini received her Bachelor of Science (Honours) with Highest Distinction/ First Class Honours in Life Sciences from National University of Singapore (NUS) in 2016, supported by ASEAN Undergraduate Scholarship. During her final year project, she investigated the role of conserved kinases and phosphatases in cell polarization, using RNAi-based screen in C. elegans under the supervision of Dr. Fumio Motegi at Temasek Life Sciences Laboratory (TLL) and Mechanobiology Institute (MBI) in Singapore. Her accomplishments culminated in the Lijen Industrial Development Medal, Student Achievement Award, and Dean’s List Recipient in 2016. Prior to her undergraduate study, she attended Republic Polytechnic (RP) in Singapore and obtained her diploma in Biotechnology with Diploma Gold Medal Award and Merit Award. Darshini joined our lab and started her graduate study in January 2017. In the Saheki lab, Darshini aims to study the neuronal regulation of cellular lipid homeostasis using C. elegans as a primary model system. Native of Malaysia, Darshini enjoys her life in Singapore and frequently visits her family in Johor Bahru.
Jingbo received his Ph.D. from State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing in 2016 under supervision of Professor Tonglin Mao. Prior to his graduate studies, Jingbo attended Weifang University, obtaining his Bachelor of Science in Seed Science and Engineering. Being supported by Chinese Government Scholarship for Graduate Studies, Jingbo studied the molecular mechanisms of microtubule-based hypocotyl cell elongation in response to ethylene using Arabidopsis as a model system. He published his findings in Plant Physiology and Journal of Cell Science as a first author. He also collaborated with other members of the Mao lab and published several articles in The Plant Cell as a co-author. In the Saheki lab, Jingbo studies the molecular mechanisms that regulate the formation and maintenance of membrane contact sites.
Loges finished his Ph.D. work at the Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, the University of Melbourne, Australia, in 2017 under supervision of Dr. Melissa Call and Dr. Matthew Call. Prior to his graduate studies, Loges attended the University of Melbourne, obtaining his Bachelor of Science with Honours in Biotechnology with High Distinction. Loges studied the transmembrane interactions within the eight-subunit T-cell receptor complex using biochemistry, NMR and mutagenesis. He published his findings in Proceedings of the National Academy of Sciences of the United States of America (PNAS) as a first author and co-authored a method paper in Journal of Visualized Experiments (JoVE). In the Saheki lab, Loges aims to study the mechanisms that govern the cellular lipid compartmentalization using biochemistry and cell biology.
Dhakshenya received her Bachelor of Science in Biomedical Sciences from Imperial College London, UK, in 2017. During her final year project, she explored isothermal DNA amplification techniques for the detection of breast cancer mutations using microchip technology in Christofer Toumazou’s lab. Dhakshenya joined us and started her graduate study in January 2018. In the Saheki lab, Dhakshenya aims to study the mechanisms of cellular lipid homeostasis focusing on the roles played by membrane contact sites. Dhakshenya is native of Singapore and besides training to be a scientist, is an aspiring Street Latin dancer.
Yun Xuan (Philip) Ngo Undergraduate Student Nanyang Technological University, School of Biological Sciences (April 2017 - )
Previous Lab Members
Chek Mei Bok, M.Sc. Research Associate (May 2016 -December 2017 ) Now at Genome Institute of Singapore (GIS)
Chek Mei received her Master of Science from National University of Singapore (NUS) in 2002, supported by NUS research scholarship. Prior to her graduate study, Chek Mei attended National University of Malaysia (UKM), obtaining her Bachelor of Science with First Class Honours. Before joining the Saheki lab, Check Mei worked as a research assistant at Genome Institute of Singapore (GIS) for 9 years [first in the Population Genetics/Proteomics group of Dr. Stephen Hsu I-Hong (2002-2006), and later in the Infectious Disease group of Dr. Martin Lloyd Hibberd (2006-2011)], developing her skills in molecular biology, mammalian cell culture, and handling rodent disease models. With her extensive research experiences, Chek Mei contributes to our lab as a skilled lab manger and pursues her interest in neuroscience research.
Naoki Arasaki Visiting Undergraduate Student University of the Ryukyus School of Medicine, Japan (February 2017 - March 2017) Now at University of the Ryukyus School of Medicine, Japan