9. Ott S, Xu S, Lee N, Hong IHK, Anns J, Suresh DD, Zhang Z, Harion R, Ye W, Chandramouli V, Jesuthasan S, Saheki Y, and Claridge-Chang A (2024). Kalium channelrhodopsins effectively inhibit neurons. Nature Communications. 15: 3480. PMID: 38658537.
8. Koh DHZ, Naito T, Na M, Yeap YJ, Rozario P, Zhong FL, Lim KL, and Saheki Y** (2023). Visualization of accessible cholesterol using a GRAM domain-based biosensor. Nature Communications. 14: 6773. PMID: 37880244.Featured by the LKCMedicine newsletter.
7. Naito T, Yang H, Koh DHZ, Mahajan D, Lu L, and Saheki Y** (2023). Regulation of cellular cholesterol distribution via non-vesicular lipid transport at ER-Golgi contact sites. Nature Communications. 14: 5867. PMID: 37735529.Featured by the Straits Times. 6. Jeyasimman D, Ercan B*, Dharmawan D*, Naito T, Sun J, and Saheki Y** (2021). PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans. Nature Communications. 12: 6065. PMID: 34663803. Featured in "Editor's Highlights". Featured by the LKCMedicine newsletter.
5. Kinnebrew M, Luchetti G, Sircar R, Frigui S, Viti LV, Naito T, Beckert F, Saheki Y, Siebold C, Radhakrishnan A, and Rohatgi R (2021). Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes. eLife. 10: e70504. PMID: 34698632.
4. Sun J*, Harion R*, Naito T, and Saheki Y** (2021). INPP5K and Atlastin-1 maintain the nonuniform distribution of ER-plasma membrane contacts in neurons. Life Science Alliance. 4: e202101092. PMID: 34556534.
3. Ercan B*, Naito T*, Koh DHZ, Dharmawan D, and Saheki Y** (2021). Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b. EMBO J. 40: e106524. PMID: 33604931.Featured by the LKCMedicine newsletter.
2. Naito T, Ercan B, Krshnan L, Triebl A, Koh DHZ, Wei FY, Tomizawa K, Torta F, Wenk MR, and Saheki Y** (2019). Movement of accessible plasma membrane cholesterol by GRAMD1 lipid transfer protein complex. eLife. 8: e51401. PMID: 31724953. eLife digest.
1. Bian X, Saheki Y**, and De Camilli P** (2018). Ca2+ releases E-Syt1 autoinhibition to couple ER-plasma membrane tethering with lipid transport. EMBO J. 37: 219-234. PMID: 29222176.
Review Articles
6. Koh DHZ, and Saheki Y** (2021). Regulation of plasma membrane sterol homeostasis by non-vesicular lipid transport. Contact (Thousand Oaks). 4: 1-17. http://doi.org/10.1177/25152564211042451.
3. Saheki Y** (2017) . Endoplasmic reticulum - plasma membrane crosstalk mediated by the extended synaptotagmins. Organelle Contact Sites - From Molecular Mechanism to Disease, Chapter 6 (83-93) Springer Press. Adv Exp Med Biol.997: 83-93. PMID: 28815523. 2. Saheki Y**, and De Camilli P** (2017). Endoplasmic reticulum - plasma membrane contact sites. Annu Rev Biochem.86: 659-684. PMID: 28301744.
1. Saheki Y**, and De Camilli P** (2017). The extended-synaptotagmins. Biochim Biophys Acta Mol Cell Res. 1864: 1490-1493. PMID: 28363589.
Other Peer-Reviewed Publications
2. Zhang D, Saheki Y, Hu J, and Kornmann B (2021). Editorial: Coupling and Uncoupling: Dynamic Control of Membrane Contacts. Front. Cell Dev. Biol. 9: 721546. PMID: 34504844.
1. Levine T, Perez F, Saheki Y, and von Blume J (2019). Meeting Report From the 2019 “Organelle Zone” Symposium in Osaka, Japan. Contact (Thousand Oaks). 2: 2515256419877091. PMID: 31588423.
Prior to LKCMedicine
13. Huang YC, Pirri J, Rayes D, Gao S, Mulcahy B, Grant J, Saheki Y, Francis M, Zhen M, and Alkema M (2019). Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in C. elegans. eLife. 8: e45905. PMID: 31364988.
12. Dong R, Saheki Y, Swarup S, Lucast L, Harper JW, and De Camilli P (2016). Endosome-ER contacts control actin nucleation and retromer function through VAP-dependent regulation of PI4P. Cell. 166: 408-423. PMID: 27419871. 11. Saheki Y, Bian X*, Schauder CM*, Sawaki Y, Surma MA, Klose C, Pincet F, Reinisch KM, and De Camilli P (2016). Control of plasma membrane lipid homeostasis by the extended synaptotagmins. Nat Cell Biol. 18: 504-15. PMID: 27065097. News and Views in Nat Cell Biol. 18: 461-3. Recommended in Faculty 1000. *Equal contribution.
10. Fernández-Busnadiego R*, Saheki Y*, and De Camilli P (2015). Three dimensional architecture of extended synaptotagmin-mediated ER-plasma membrane contact sites. Proc Natl Acad Sci U S A. 112: E2004-13. PMID: 25787254. Commentary in Proc Natl Acad Sci U S A. 112: 4837-8. *Co-first authors.
9. Schauder CM, Wu X*, Saheki Y*, Narayanaswamy P, Torta F, Wenk MR, De Camilli P, and Reinisch KM (2014). Structure of a lipid-bound extended-synaptotagmin indicates a role in lipid transfer. Nature. 510: 552-5. PMID: 24847877. Recommended in Faculty 1000. *Equal contribution.
8. Giordano F*, Saheki Y*, Idevall-Hagren O, Colombo S, Pirruccello M, Milosevic I, Gracheva EO, Sviatoslav BN, Borgese N, and De Camilli P (2013). PI(4,5)P2 dependent and Ca2+-regulated ER-plasma membrane interactions mediated by the extended synaptotagmins. Cell. 153: 1494-509. PMID: 23791178. Preview in Cell. 153: 1423-1424. Recommended in Faculty 1000. *Co-first authors.
7. Saheki Y, and De Camilli P (2012). Synaptic vesicle endocytosis. The Synapse, Chapter 5 (79-108) Cold Spring Harbor Lab Press. 4: a005645. PMID: 22763746. Cover article. 6. Saheki Y, and Bargmann CI (2009). Presynaptic CaV2 calcium channel traffic requires CALF-1 and the alpha (2) delta subunit UNC-36. Nat Neurosci. 12: 1257-65. PMID: 19718034. News and Views in Nat Neurosci. 12: 1213-4. Recommended in Faculty 1000.
5. Bauer Huang SL, Saheki Y, VanHoven MK, Torayama I, Ishihara T, Katsura I, van der Linden A, Sengupta P, and Bargmann CI (2007). Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans. Neural Dev. 2: 24. PMID: 17986337.
4. Ueki Y, Lin CY, Senoo M, Ebihara T, Agata N, Onji M, Saheki Y, Kawai T, Mukherjee PM, Reichenberger E, and Olsen BR (2007). Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell. 128: 71-83. PMID: 17218256.
3. Wei FY, Nagashima K, Ohshima T, Saheki Y, Lu YF, Matsushita M, Yamada Y, Mikoshiba K, Seino Y, Matsui H, and Tomizawa K (2005). Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat Med. 11: 1104-1108. PMID: 16155576.
2. Saheki Y, Li ST, Matsushita M, Wu YM, Cai WH, Wei FY, Lu YF, Moriwaki A, Tomizawa K, and Matsui H (2005). A new approach to inhibiting astrocytic IP3-induced intracellular calcium increase in an astrocyte-neuron co-culture system. Brain Res. 1055: 196-201. PMID: 16099437.
1. Li ST, Matsushita M, Moriwaki A, Saheki Y, Lu YF, Tomizawa K, Wu HY, Terada H, and Matsui H (2004). HIV-1 Tat inhibits long-term potentiation and attenuates spatial learning. Ann Neurol. 55: 362-71. PMID: 14991814.