Key Publications

1. Sun J*, Harion R*, Naito T, and Saheki Y** (2021). INPP5K and Atlastin-1 maintain the nonuniform distribution of ER-plasma membrane contacts in neurons. Life Science Alliance. *Co-first authors. **Corresponding author, in press

2. Koh DHZ, and Saheki Y* (2021). Regulation of plasma membrane sterol homeostasis by non-vesicular lipid transport. Contact (Thousand Oaks). *Corresponding author  (review article), in press

3. Naito T, and Saheki Y* (2021). GRAMD1-mediated accessible cholesterol sensing and transport.  Biochim Biophys Acta Mol Cell Biol Lipids. PMID: 3393285 *Corresponding author  (review article)

4. Ercan B*, Naito T*, Koh DHZ, Dharmawan D, and Saheki Y** (2021). Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b. EMBO J. e106524 *Co-first authors. **Corresponding author

5. Naito T, Ercan B, Krshnan L, Triebl A, Koh DHZ, Wei FY, Tomizawa K, Torta F, Wenk MR, and Saheki Y* (2019). Movement of accessible plasma membrane cholesterol by GRAMD1 lipid transfer protein complex. eLife. PMID: 31724953. *Corresponding author. eLife digest

6. Jeyasimman D, and Saheki Y* (2019). SMP domain proteins in membrane lipid dynamics. Biochim Biophy Acta Mol Cell Biol Lipids.  PMID: 31002947. *Corresponding author  (review article) 

7. Bian X, Saheki Y*, and De Camilli P* (2018). Ca2+ releases E-Syt1 autoinhibition to couple ER-plasma membrane tethering with lipid transport. EMBO J. PMID: 29222176. *Corresponding author

8. Saheki Y*, and De Camilli P* (2017). Endoplasmic reticulum - plasma membrane contact sites. Annu Rev Biochem. 86, 659-684 PMID: 28301744. *Corresponding author  (review article) 

9. Saheki Y*, and De Camilli P* (2017). The extended-synaptotagmins. Biochim Biophys Acta. 9, 1490-1493 PMID: 28363589. *Corresponding author. Cover Article (review article)

10. Dong R, Saheki Y, Swarup S, Lucast L, Harper JW, and De Camilli P (2016). Endosome-ER contacts control actin nucleation and retromer function through VAP-dependent regulation of PI4P. Cell. 166, 408-423 PMID: 27419871.
 
11. Saheki Y, Bian X*, Schauder CM*, Sawaki Y, Surma MA, Klose C, Pincet F, Reinisch KM, and De Camilli P (2016). Control of plasma membrane lipid homeostasis by the extended synaptotagmins. Nat Cell Biol. 5, 504-15 PMID: 27065097. News and Views in Nat Cell Biol. 5, 461-3 (2016)  Recommended in Faculty 1000. *Equal contribution

12. Fernández-Busnadiego R*, Saheki Y*, and De Camilli P (2015). Three dimensional architecture of extended synaptotagmin-mediated ER-plasma membrane contact sites. Proc Natl Acad Sci U S A. 112(16): E2004-13 PMID: 25787254. Commentary in Proc Natl Acad Sci U S A, 112(16):4837-8 (2015). *Co-first authors

13. Schauder CM, Wu X*, Saheki Y*, Narayanaswamy P, Torta F, Wenk MR, De Camilli P, and Reinisch KM (2014). Structure of a lipid-bound extended-synaptotagmin indicates a role in lipid transfer. Nature. 510, 552-5 PMID: 24847877. Recommended in Faculty 1000. *Equal contribution

14. Giordano F*, Saheki Y*, Idevall-Hagren O, Colombo S, Pirruccello M, Milosevic I, Gracheva EO, Sviatoslav BN, Borgese N, and De Camilli P (2013). PI(4,5)P2 dependent and Ca2+-regulated ER-plasma membrane interactions mediated by the extended synaptotagmins. Cell. 153, 1494-509 PMID: 23791178. Preview in Cell, 153, 1423-1424 (2013). Recommended in Faculty 1000. *Co-first authors
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15. Saheki Y, and Bargmann CI (2009). Presynaptic CaV2 calcium channel traffic requires CALF-1 and the alpha (2) delta subunit UNC-36. Nat Neurosci. 10, 1257-65 PMID: 19718034. News and Views in Nat Neurosci. 10, 1213-4 (2009). Recommended in Faculty 1000.
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Book Chapters

1. Saheki Y* (2017) . Endoplasmic reticulum - plasma membrane crosstalk mediated by the extended synaptotagmins. Organelle Contact Sites - From Molecular Mechanism to Disease, Chapter 6 (83-93) PMID: 28815523. Springer Press. Textbook Chapter. *Corresponding author.

2. Saheki Y, and De Camilli P (2012). Synaptic vesicle endocytosis. The Synapse, Chapter 5 (79-108) PMID: 22763746. Cold Spring Harbor Lab Press. Textbook Chapter. Cover article.

Other Peer-reviewed Publications

1. Zhang D, Saheki Y, Hu J, and Kornmann B. (2021). Editorial: Coupling and Uncoupling: Dynamic Control of Membrane Contacts. Front. Cell Dev. Biol. doi: 10.3389/fcell.2021.721546.

2. Levine T, Perez Franck, Saheki Y, and Julia von Blume (2019). Meeting Report From the 2019 “Organelle Zone” Symposium in Osaka, Japan. Contact. 1, 2 PMID: 31588423.

3. Huang YC, Pirri J, Rayes D, Gao S, Mulcahy B, Grant J, Saheki Y, Francis M, Zhen M, and Alkema M (2019). Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in C. elegans. eLife. 5, 8 PMID: 31364988.

4. Bauer Huang SL, Saheki Y, VanHoven MK, Torayama I, Ishihara T, Katsura I, van der Linden A, Sengupta P, and Bargmann CI (2007). Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans. Neural Dev. 2, 24 PMID: 17986337.

5. Ueki Y, Lin CY, Senoo M, Ebihara T, Agata N, Onji M, Saheki Y, Kawai T, Mukherjee PM, Reichenberger E, and Olsen BR (2007). Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell. 128, 71-83 PMID: 17218256.

6. Wei FY, Nagashima K, Ohshima T, Saheki Y, Lu YF, Matsushita M, Yamada Y, Mikoshiba K, Seino Y, Matsui H, and Tomizawa K (2005). Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat Med. 11, 1104-1108 PMID: 16155576.

7. Saheki Y, Li ST, Matsushita M, Wu YM, Cai WH, Wei FY, Lu YF, Moriwaki A, Tomizawa K, and Matsui H (2005). A new approach to inhibiting astrocytic IP3-induced intracellular calcium increase in an astrocyte-neuron co-culture system. Brain Res. 1055, 196-201 PMID: 16099437.

8. Li ST, Matsushita M, Moriwaki A, Saheki Y, Lu YF, Tomizawa K, Wu HY, Terada H, and Matsui H (2004). HIV-1 Tat inhibits long-term potentiation and attenuates spatial learning. Ann Neurol. 55, 362-71 PMID: 14991814.
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